GHK Basic (Topical)

GHK Basic (Tripeptide-1) 50mg (Topical)

GHK Basic, also known as Tripeptide-1, is a naturally occurring tripeptide made of glycine, histidine, and lysine. It is present in human plasma and forms a strong bond with copper ions. This creates a compound called GHK-Cu, often used in research to study its impact on skin health and cellular processes.

Researchers are interested in how this peptide affects biological systems. Primarily, it has been linked to changes in gene expression, cellular signaling, and the behavior of skin cells. Its small amino acid sequence allows it to interact with multiple cellular receptors and influence various physiological processes. [1]

In vitro studies suggest it plays a part in tissue regeneration, inflammation response, and the maintenance of tissue integrity. This peptide has also become a target of interest in research exploring how peptides influence oxidative stress, DNA repair, and the activation of growth factors such as vascular endothelial growth factor.

Potential Benefits of GHK Basic Topical Peptide

Studies on GHK Basic have revealed its ability to support collagen synthesis and skin repair. This makes it a strong candidate for investigating how skin structure changes under stress or injury. In research models, GHK Basic has promoted collagen production, helping restore the extracellular matrix and improve the condition of damaged tissues. [2]

One area of focus has been wound healing. Research suggests GHK Basic may speed up wound contraction and influence the movement of cells to injury sites.

It may also helps in the release and action of fibroblast growth factor, which helps in tissue remodeling. In skin research, this peptide has supported the regeneration of dermal skin equivalents and improved the proliferative potential of basal keratinocytes.

GHK Basic also appears to affect oxidative damage. It has been studied for its ability to reduce the impact of reactive oxygen species and limit lipid peroxidation. These processes, if left unchecked, lead to skin aging and tissue breakdown. By controlling oxidative stress, GHK Basic may help maintain cellular balance during tissue repair studies.

Its ability to alter gene expression is another important discovery. Scientists have observed changes in the gene pattern characteristic of healthy stem cells after exposure to GHK Basic.

In studies, this peptide influenced the expression of genes linked to DNA repair, inflammation control, and cell migration. The restoration of these patterns is considered a major step in supporting the body’s natural healing signals.

The tripeptide’s interaction with copper ions has also been a major point of interest. Copper plays a vital role in the formation of new blood vessels (angiogenesis), a necessary step in tissue repair. It’s strong copper affinity supports studies on blood vessel formation and the expression of vascular endothelial growth factor in endothelial cells.

GHK Basic has been studied not only in skin research but also in systemic models. It may help regulate cytokines, reduce inflammation, and modulate immune function.

In one direction of peptide therapy research, its ability to reduce oxidative stress in tissues such as the lungs is being further investigated. [3] Other areas of interest include hair follicle activity and the prevention of damage from UV exposure. [4]

While these results are promising, GHK Basic is for research use only. This peptide is not approved for therapeutic use, consumption, or the prevention of any disease.

How Should GHK Basic Be Stored?

GHK Basic should be kept in a cool and dry environment to maintain its biological activity. Temperatures between 2°C and 8°C are ideal. For longer-term use, storing the peptide at –20°C is common in lab settings.

It should be shielded from light, moisture, and repeated freeze-thaw cycles. These conditions can degrade the peptide and alter its amino acid structure. If reconstituted in a solution, such as a liposome system, use should be immediate, and the container should remain sealed to avoid contamination.

Proper storage ensures GHK Basic maintains its structure for use in future research related to skin biology, oxidative stress, and tissue regeneration.

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References:

[1] Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987.

[2] Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015;2015:648108.

[3] Park JR, Lee H, Kim SI, Yang SR. The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice. Oncotarget. 2016 Sep 6;7(36):58405-58417.

[4] Cebrián J, Messeguer A, Facino RM, García Antón JM. New anti-RNS and -RCS products for cosmetic treatment. Int J Cosmet Sci. 2005 Oct;27(5):271-8.

Molecular formula: C14H24N6O4

Molecular weight: 340.38

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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our New Zealand Direct Peptides website: https://new-zealand.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

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